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Novel Salivary Biomarker for Cognitive Impairment

07426

Saliva-based sTREM2 biomarker enables noninvasive early detection of cognitive impairment and dementia risk.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Neuroscience
Therapeutic Indications: Alzheimer's Disease
Tags: Life Science
Biomarker
In Vitro Diagnostic
Lead Inventor: Tharick Ali Pascoal
Department: Med-Psychiatry
All Tech Innovators: Tharick Ali Pascoal
Daniel Robert Clark
Date Submitted: 2025-12-09

TIPS: Smartphone-Based Training for ADHD

07201

Smartphone-m health app TIPS delivers personalized, real-time ADHD strategies to curb symptoms and risky drinking behaviors.

Technology Type: Digital Health
Technology Subtype: Other Digital Health
Therapeutic Areas: Mental and Behavioral Health
Tags: Life Science
Lead Inventor: Traci Kennedy
Department: Med-Psychiatry
All Tech Innovators: Traci M. Kennedy
Date Submitted: 2025-05-31

Novel Treatment for Acetaminophen-Induced Acute Liver Failure

07480

EGFR inhibitors afatinib and osimertinib may treat delayed acetaminophen-induced liver failure, reducing damage and supporting regeneration.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Hepatology
Tags: Life Science
Drug Discovery - Target
Liver Disease
Lead Inventor: Bharat Bhushan
Department: Med-Pathology
All Tech Innovators: Bharat Bhushan
George Michalopoulos
Date Submitted: 2026-02-11

Novel Therapy for Sepsis

07388

A novel polypeptide YPD-203 targets sepsis-induced cytokine surges, reducing organ damage and improving survival in animal models.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Therapeutic Areas: Infectious Disease
Therapeutic Indications: Sepsis
Tags: Life Science
Peptide
Drug Discovery - Target
Lead Inventor: Yuanpu Di
All Tech Innovators: Yuanpu Di
Date Submitted: 2025-10-24

Immunotherapy for Neuroblastoma and Ewing Sarcoma

07259

GFRA2-targeted, fully humanized antibodies enable precise neuroblastoma/Ewing sarcoma therapies (CAR-T, ADCs) with potential imaging uses.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Oncology
Therapeutic Indications: Neuroblastoma
Glioblastoma
Tags: Life Science
Lead Inventor: Wei Li
Department: Med-Medicine
All Tech Innovators: Sharon Diskin
Amber Hamilton
Michelle Keyel
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2025-07-29

Novel Biomarker for Cervical Spondylotic Myelopathy

07261

Blood-based biomarker panel with ML predicts CSM diagnosis, severity, prognosis, and treatment response, reducing invasive testing.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Neuroscience
Tags: Life Science
Aging
Biomarker
Lead Inventor: Nitin Agarwal
Department: Med-Neurological Surgery
All Tech Innovators: Nitin Agarwal
Sameer Agnihotri
David Kojo Hamilton
Date Submitted: 2025-07-24

Novel Repair and Regeneration Therapy for Glaucoma

07246

AAV-Ina overexpression promotes retinal ganglion cell survival and axon regeneration, offering neuroprotection for glaucoma with regeneration potential.

Technology Type: Therapeutic Modality
Therapeutic Areas: Neuroscience
Ophthalmology
Therapeutic Indications: Glaucoma
Tags: Life Science
Drug Discovery - Target
Lead Inventor: Kun Che Chang
Department: Med-Ophthalmology
All Tech Innovators: Kun Che Chang
Chi-Yu Chen
Date Submitted: 2025-07-11

Novel Therapy to Prevent Organ Transplant Rejection

06909

WS6 inhibitor targets tissue-resident memory T cells, potentially preventing organ transplant rejection with reduced broad immunosuppression.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Immunology
Therapeutic Indications: Other
Tags: Life Science
Drug Discovery - Target
Lead Inventor: Khodor Abou Daya
Department: Med-Surgery
All Tech Innovators: Khodor Abou Daya
Date Submitted: 2024-10-01

Small Molecule Drug for Targeting Resistant Prostate Cancer

07323

New class of nuclear AR-degrading small molecules (NARDs) selectively targets resistant prostate cancer by degrading AR in the nucleus.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Oncology
Tags: Life Science
Oncology
Lead Inventor: Peter Wipf
Department: Chemistry
All Tech Innovators: Timothy James Casad
Joel B. Nelson
Zhou Wang
Date Submitted: 2025-09-02

Hibernation-Inspired Protein Reverses Fatty Liver Disease and Obesity

07317

Hibernation-inspired siRNA therapy silences SULT1C2 to reverse fatty liver disease and obesity in preclinical models.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Endocrinology and Metabolic Diseases
Hepatology
Therapeutic Indications: Obesity
Metabolic Associated Fatty Liver Disease (MAFLD)
Tags: Life Science
Lead Inventor: Alejandro Soto Gutierrez
Department: Med-Pathology
All Tech Innovators: Lanuza Alaby Pinheiro Alaby Pinheiro Faccioli
Bharat Bhushan
Rodrigo Machado Florentino
Date Submitted: 2025-08-29
Collections: Cell & Gene Therapy
Cardiometabolic

Novel Biomarker for Peridontal Disease

07268

Saliva-based sTREM2 biomarker enables noninvasive early detection of periodontal disease, guiding implant/surgical decisions.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Immunology
Therapeutic Indications: Inflammation - General
Tags: Life Science
Biomarker
In Vitro Diagnostic
Lead Inventor: Daniel Clark
Department: Dent Med-Periodontics/Preventive Dentistry
All Tech Innovators: Tharick Ali Pascoal
Daniel Robert Clark
Date Submitted: 2025-07-29
Collections: Regenerative Medicine

Novel Contrast-Enhanced Mammography Method

07208

AI-driven automated quantification of background parenchymal enhancement in contrast-enhanced mammography for standardized risk prediction and workflow.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Reproductive Health
Therapeutic Indications: Obstetrics
Tags: Life Science
Clinical Decision Support
Diagnostic Imaging
Lead Inventor: Tamerlan Mustafaev
Department: Med-Radiology
All Tech Innovators: Ju Hun Lee
Tamerlan Mustafaev
Robert Mark Nishikawa
Date Submitted: 2025-06-05
Collections: Women's & Reproductive Health
Healthcare AI

Novel Therapy for Chondrocyte Aging and Osteoarthritis

07004

GATA4-targeting small molecule HCA42027 may restore aged chondrocyte repair, offering a potential disease-modifying OA therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Musculoskeletal
Therapeutic Indications: Heart failure
Atherosclerotic disease
Osteoarthritis
Tags: Life Science
Drug Discovery - Target
Lead Inventor: Hang Lin
Department: Med-Orthopedic Surgery
All Tech Innovators: Olivia Bartholomew
Kate Li
Hang Lin
Date Submitted: 2024-12-11
Collections: Cardiometabolic

Novel Treatment for Neuroblastoma and Ewing Sarcoma

07186

Fully human GFRA2-targeting antibodies enable potential NB/ES immunotherapies (ADCs, CAR-T, bispecifics) with reduced off-target effects.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Oncology
Therapeutic Indications: Glioblastoma
Tags: Life Science
Lead Inventor: Wei Li
Department: Med-Medicine
All Tech Innovators: Sharon Diskin
Amber Hamilton
Wei Li
Date Submitted: 2025-05-14

Biomarkers for Diagnosis of Ear and Sinus Infections

07147

Novel nasal IL-1a biomarker plus symptom algorithm improves pediatric bacterial sinusitis diagnosis, guiding antibiotic use.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Otolaryngology
Tags: Life Science
Biomarker
Clinical Decision Support
Lead Inventor: Nader Shaikh
Department: Med-Pediatrics
All Tech Innovators: Nader Shaikh
Date Submitted: 2025-04-11

Novel Antiviral Therapy for H5N1 Influenza

07141

Novel antiviral peptide targets H5N1 HA, enabling nasal/aerosol delivery; broad clade activity and pandemic preparedness potential.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Therapeutic Areas: Infectious Disease
Tags: Life Science
Lead Inventor: Suresh V Kuchipudi
Department: GSPH-Infectious Diseases & Microbiology
All Tech Innovators: Suresh V Kuchipudi
Date Submitted: 2025-04-06

Personalized Assembloids as AMD Models

06978

Patient-specific 3D AMD model: hiPSC-derived retinal layers with a biomimetic Bruch’s membrane on a perfusable choroidal vasculature.

Technology Type: Life Science Research Tool
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Age-related macular degeneration
Tags: Life Science
Lead Inventor: Jonathan Vande Geest
Department: Bioengineering
All Tech Innovators: Jay Kumar Chhablani
Jincy Joy
Susana Isabel Morgado Mendes Antunes da>VF
Date Submitted: 2024-11-15

Anti-Inflammatory Biotherapeutics for Eye Wound

06908

Engineered eye-colonizing bacteria deliver human IL-10 to corneal wounds, accelerating healing with sustained anti-inflammatory therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Protein
Therapeutic Areas: Ophthalmology
Therapeutic Indications: Ocular hypertension
Tags: Life Science
Lead Inventor: Anthony St Leger
Department: Med-Ophthalmology
All Tech Innovators: Jackie Lynn Shane
Anthony J. St Leger
Date Submitted: 2024-09-30
Collections: Regenerative Medicine

HART: Health App Review Tool

07091

HART tailors health app recommendations for ADRD patients via four-domain assessment, guiding clinicians, patients, and caregivers.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Neuroscience
Therapeutic Indications: Dementia
Alzheimer's Disease
Tags: Life Science
Clinical Decision Support
Lead Inventor: Julie Faieta
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: Yong Kyung Choi
Julie Marie Faieta
Haomin Hu
Date Submitted: 2025-02-24

Extracorporeal Human Brain Perfusion Platform

06814

Ex vivo human brain perfusion platform enables live brain tissue stimulation, recording, and analysis under near-physiological conditions.

Technology Type: Life Science Research Tool
Technology Subtype: Other Life Science Research Tool
Therapeutic Areas: Neuroscience
Tags: Life Science
Brain-computer interface
Lead Inventor: Pascal Zinn
Department: Med-Neurological Surgery
All Tech Innovators: Pascal Oliver Zinn
Date Submitted: 2024-07-19

Endosomal Lysis for mRNA Induced Protein Expression

06986

Endosomal lysis via Flag-289 enhances mRNA release and protein expression in liposome-delivered therapies without pyroptosis.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Infectious Disease
Tags: Life Science
Lead Inventor: Yi-Nan Gong
Department: Med-Immunology
All Tech Innovators: Yi-Nan Gong
Reinhard Hinterleitner
Donghui Yang
Date Submitted: 2024-11-27

Streamlined Resource–Efficient Assay for Amyloid-β

06792

A streamlined IP-MS assay uses a common buffer to quantify plasma amyloid-β biomarkers, enabling affordable, noninvasive AD monitoring.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Neuroscience
Therapeutic Indications: Alzheimer's Disease
Tags: Life Science
In Vitro Diagnostic
Lead Inventor: Thomas Karikari
Department: Med-Psychiatry
All Tech Innovators: Yijun Chen
Thomas K. Karikari
Nathan A. Yates
Date Submitted: 2024-07-05

Novel Influenza D Virus Vaccine Strategy

06964

Single-cycle M-null IDV vaccine prompts strong immunity without disease, offering cross-species protection for cattle, swine, and humans.

Technology Type: Therapeutic Modality
Technology Subtype: Vaccine - subunit, recombinant, polysaccharide, or conjugate
Therapeutic Areas: Infectious Disease
Therapeutic Indications: Influenza
Tags: Life Science
Lead Inventor: Suresh V Kuchipudi
Department: GSPH-Infectious Diseases & Microbiology
All Tech Innovators: Suresh V Kuchipudi
Santhamani Ramasamy
Date Submitted: 2024-11-08

Novel Biomarker for Personalizing Cancer

06959

A 10-gene type-I interferon/exhaustion signature in CD8+ TIL predicts and personalizes HNSCC ICI responses.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Oncology
Tags: Life Science
Biomarker
Personalized Medicine
Lead Inventor: Robert Ferris
Department: Med-Otolaryngology
All Tech Innovators: Robert Louis Ferris
Housaiyin Li
Lazar Nikola Vujanovic
Date Submitted: 2024-11-06

Non-Replicating SARS-CoV-2 for Safer Research

06926

Replication-defective SARS-CoV-2 enables safer, BSL-2 research; single-cycle, reporter-enabled tools for vaccines and therapies.

Technology Type: Life Science Research Tool
Technology Subtype: Nucleic Acid
Therapeutic Areas: Infectious Disease
Therapeutic Indications: Covid-19
Tags: Life Science
Lead Inventor: Zandrea Ambrose
Department: Med-Microbiology and Molecular Genetics
All Tech Innovators: Zandrea Ambrose
Hannah Leah Fischer
Christopher J. Kline
Date Submitted: 2024-10-16

spatiAlytica: Intuitive Spatial Transcriptomic Discovery

06888

AI-enabled spatiAlytica transforms spatial transcriptomics: natural-language queries generate real-time Python analysis, no coding needed.

Technology Type: Life Science Research Tool
Technology Subtype: Bioinformatics
Tags: Life Science
Artificial intelligence (AI)
Software
Lead Inventor: Yufei Huang
Department: Med-Medicine
All Tech Innovators: Arun Das
Yufei Huang
Date Submitted: 2024-09-20
Collections: Healthcare AI

Fin Thruster on Acoustic Resonator for Swimming Robots

06864

Acoustic resonator fins enable tunable, long-lasting microrobots propelling up to 0.6 m/s for targeted in-body navigation.

Technology Type: Medical Device
Technology Subtype: Other Medical Device
Tags: Life Science
Precision medicine
Lead Inventor: Sung Kwon Cho
Department: Mechanical Engineering and Materials Science
All Tech Innovators: Sung Kwon Cho
Wenbo Li
Date Submitted: 2024-09-04

Novel Carbon Monoxide Poisoning Antidote

06836

Engineered hemeprotein-immobilized resin extracorporeally scavenges carbon monoxide, offering a safer, reusable antidote via dialysis-like device.

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Hematology
Tags: Life Science
Lead Inventor: Jesus Tejero Bravo
Department: Med-Medicine
All Tech Innovators: Madison Butler
William J. Federspiel
Mark Thomas Gladwin
Date Submitted: 2024-08-09

Novel Llama Nanobody to Treat HIV-1

06827

Humanized llama nanobody 4E2 neutralizes diverse HIV-1 strains, offering a potential long-term, low-immunogenic therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Immunology
Infectious Disease
Therapeutic Indications: HIV
Tags: Life Science
Drug Discovery - Target
Lead Inventor: Wei Li
Department: Med-Medicine
All Tech Innovators: Zhiwei Feng
Margaret Grace Hines
Wei Li
Date Submitted: 2024-07-26
Collections: Women's & Reproductive Health
Healthcare AI

Borylated Esters and Acetals as Cancer Prodrugs

06731

Boronate-protected prodrugs release cytotoxins in peroxide-rich cancer cells, enabling targeted, reduced-side-effect chemotherapy.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Oncology
Tags: Life Science
Lead Inventor: Paul Floreancig
Department: Chemistry
All Tech Innovators: Alexander Deiters
Paul Edward Floreancig
Paul Joseph Geaneotes
Date Submitted: 2024-04-29

High-Density Micro-Invasive Array for Brain Monitoring

06812

High-density, dissolvable carbon-fiber brain electrodes enable simultaneous neurochemical and electrical monitoring for deep-brain studies and stimulation.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Neuroscience
Tags: Life Science
Implantable Medical Device
Lead Inventor: Helen Schwerdt
Department: Bioengineering
All Tech Innovators: Shreya Mahajan
Helen Schwerdt
Ritesh Shrivastav
Date Submitted: 2024-07-18

Novel Research Model for Liver Dysfunction

06810

Researchers create TM6SF2-167K iPSC-derived liver cells to model MASLD, enabling target discovery and therapy screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Hepatology
Therapeutic Indications: Cirrhosis
Tags: Life Science
Drug Discovery - Target
Lead Inventor: Alejandro Soto Gutierrez
Department: Med-Pathology
All Tech Innovators: Lanuza Alaby Pinheiro Alaby Pinheiro Faccioli
Rodrigo Machado Florentino
Alejandro Soto Gutierrez
Date Submitted: 2024-07-17
Collections: Cardiometabolic

Treatment for Pediatric Bronchopulmonary Dysplasia

06694

Oral vamorolone may treat infant bronchopulmonary dysplasia safely, reducing long-term steroid risks and growth impacts.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Respiratory
Therapeutic Indications: Other
Tags: Life Science
Pediatrics
Lead Inventor: Donald DeFranco
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Timothy Cole
Donald B. DeFranco
Nathalie El Khoury Juri
Date Submitted: 2024-03-19

Pittsburgh Reproducibility Protocol (PReP)

06749

PReP standardizes reproducibility checks in microphysiological systems using CV, ANOVA, and ICC to separate variability from biology.

Technology Type: Digital Health
Technology Subtype: Clinical Trial Tool
Tags: Life Science
Drug Development
Lead Inventor: Mark Schurdak
Department: Med-Computational and Systems Biology
All Tech Innovators: Albert H. Gough
Mark E. Schurdak
Douglass Lansing Taylor
Date Submitted: 2024-05-13

StairAbility: Adaptable Stair-Climbing Device

06626

Modular stair-climbing system adds interchangeable supports to stairlifts, aiding safer, independent stair use.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Tags: Life Science
Gerontology
Lead Inventor: Jonathan Pearlman
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: William A. Ammer B.S.
David M. Brienza Ph.D.
Joel Michael Fadness
Date Submitted: 2024-02-02

System to Control and Power Prosthetic Liners

06590

Robotic prosthetic liners powered by low-profile copper tape enable durable, wireless control for limb therapy and research.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Tags: Life Science
Therapeutic Medical Device
Lead Inventor: Kacey Roehrich
Department: All Temps
All Tech Innovators: Goeran Fiedler
Kacey Roehrich
Norah Stivala
Date Submitted: 2023-12-11

Novel Design of Cationic Antimicrobial Peptides

06604

Novel linear-amphipathic antimicrobial peptides with stabilized disulfide cycles offer potent activity and reduced toxicity against resistant pathogens.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Therapeutic Areas: Infectious Disease
Therapeutic Indications: Streptococcus
Tags: Life Science
Lead Inventor: Berthony Deslouches
Department: GSPH-Environmental/Occupational Health
All Tech Innovators: Berthony Deslouches
Date Submitted: 2024-01-08

MePhys: Mesoscopic Electrophysiology

06557

MePhys images whole primate brains with 992 intracranial and 32 skull electrodes, enabling ultra-fast, high-resolution brain connectome mapping.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Tags: Life Science
Diagnostic Imaging
Lead Inventor: Tobias Teichert
Department: Med-Psychiatry
All Tech Innovators: Tobias Teichert
Date Submitted: 2023-11-03

AI for Vascular Calcification Risk Assessment

06541

AI-driven tool stratifies vascular calcification risk via phenotyping, enabling individualized MACE prediction and targeted treatment.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Atherosclerotic disease
Tags: Life Science
Cardiology
Clinical Decision Support
Lead Inventor: Mehdi Ramezanpour Koomleh
Department: Mechanical Engineering and Materials Science
All Tech Innovators: Mehdi Ramezanpour Koomleh
Anne M. Robertson
Date Submitted: 2023-10-12
Collections: Cardiometabolic
Healthcare AI

Novel Structural and Functional Imaging of Bladder Diseases

06472

Intravesical MRI emulsion enhances bladder imaging by direct contrast instillation, improving cancer staging and permeability assessment.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Urology
Oncology
Therapeutic Indications: Overactive Bladder
Bladder
Urothelial carcinoma (Bladder cancer)
Tags: Life Science
Diagnostic Imaging
MR Contrast Agents
Lead Inventor: Pradeep Tyagi
Department: Med-Urology
All Tech Innovators: Chan-Hong Moon
Pradeep Tyagi
Date Submitted: 2023-08-02

Rapid Diagnostic Tool for Tuberculosis

06426

A fast, affordable TB diagnostic using SWCNT FET sensors detects MTB antigen 85B in minutes at fg/mL sensitivity.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Infectious Disease
Tags: Life Science
In Vitro Diagnostic
Public Health
Lead Inventor: Alexander Star
Department: Chemistry
All Tech Innovators: Michael R. Shurin
Alexander Star
Jieyu Wang
Date Submitted: 2023-06-09

Small Molecule Drugs for Acute Kidney Injury and Fibrosis

06366

Small-molecule sulfonamides UPHH-207/231 accelerate renal recovery, reduce fibrosis in AKI models, advancing non-prodrug therapy options.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Nephrology
Therapeutic Indications: Acute Kidney Injury (AKI)
Tags: Life Science
Drug Discovery - Target
Lead Inventor: Donna Huryn
All Tech Innovators: Neil A. Hukriede
Donna Huryn
Date Submitted: 2023-04-10

A Novel Therapeutic Biomarker for Metabolic Liver Disease

06324

Identifies PNPLA3 rs738409 variant driving MAFLD via ferroptosis; enables targeted therapies, screening, and safer liver transplantation.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Hepatology
Therapeutic Indications: End-Stage liver disease (ESLD)
Cirrhosis
Tags: Life Science
Drug Discovery - Target
Liver Disease
Lead Inventor: Alejandro Soto Gutierrez
Department: Med-Pathology
All Tech Innovators: Abhinav Achreja
Olamide Animasahun
Rodrigo Machado Florentino
Date Submitted: 2023-03-01
Collections: Cardiometabolic

Novel Treatment for Retinitis Pigmentosa

06383

Pyrvinium targets NS LLPS to restore proteostasis, preserve retinal structure, and may treat retinitis pigmentosa and proteinopathies.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Neuroscience
Ophthalmology
Therapeutic Indications: Parkinson's Disease
Alzheimer's Disease
Retinitis pigmentosa (RP)
Tags: Life Science
Lead Inventor: Bokai Zhu
Department: Med-Medicine
All Tech Innovators: Yuanyuan Chen
William A. Dion
Bokai Zhu
Date Submitted: 2023-04-23

Novel Immunotherapy for Hepatocellular Carcinoma

06382

Novel mAb targets MAN2A1-FER–positive cancers (HCC, prostate, glioblastoma), slowing growth and metastasis via PDGFRA extracellular domain binding.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Oncology
Therapeutic Indications: Hepatocellular carcinoma (HCC)
Tags: Life Science
Antibody - mAb
Drug Discovery - Target
Lead Inventor: Jianhua Luo
Department: Med-Pathology
All Tech Innovators: Muhamuda Kader
Jianhua Luo
Yanping Yu
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2023-04-21

Heterocyclic Compounds for Imaging Aggregated Tau

06319

New indole-based PET tracers selectively image 4R-tau in PSP/CBD, aiding early non-Alzheimer’s tauopathy diagnosis and therapy monitoring.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Therapeutic Indications: Alzheimer's Disease
Tags: Life Science
Diagnostic Imaging
Lead Inventor: Jeffrey Stehouwer
Department: Med-Radiology
All Tech Innovators: Thomas Graham
Robert H. Mach
Chester A. Mathis Jr., Ph.D.
Date Submitted: 2023-02-28

4D Oxy-Wavelet MRI for Monitoring Mitochondrial Function

06288

4D Oxy-Wavelet MRI noninvasively tracks mitochondrial function and oxygenation in live tissue with high-res, hypoxia-driven insights.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Endocrinology and Metabolic Diseases
Therapeutic Indications: Other
Mitochondrial Disease
Tags: Life Science
Pediatrics
Rare disease
Lead Inventor: Yijen Wu
Department: Med-Pediatrics
All Tech Innovators: Anthony G. Christodoulou
Devin Raine Everaldo Cortes
Yijen Wu
Date Submitted: 2023-02-13
Collections: Cardiometabolic

CIBOO: Controllable Intravesical Bladder Outlet Occulusion Device

06011

Magnet-controlled intravesical device blocks bladder outlet to prevent incontinence, removable externally for normal urination.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Urology
Therapeutic Indications: Bladder function restoration
Tags: Life Science
Implantable Medical Device
Therapeutic Medical Device
Lead Inventor: Paul Rusilko
Department: Med-Urology
All Tech Innovators: Hassan Beheshti Seresht
Youngjae Jae Chun
Roger D. Klein
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2022-04-17

Novel Selective Kv7 Channel Modulators

06017

Selective novel chemotypes selectively modulate Kv7.2 channels, enabling safer treatments for epilepsy, tinnitus, channelopathies.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Neuroscience
Cardiovascular
Tags: Life Science
Lead Inventor: Peter Wipf
Department: Chemistry
All Tech Innovators: Peter Wipf
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2022-05-02
Collections: Cardiometabolic

The Stair Guide – Supporting Active Aging

05915

New ergonomic Stair Guide System aids upright, one-handed stair ascent/descent, enabling independent aging with movable rail, patent pending.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Tags: Life Science
Gerontology
Lead Inventor: Alexandra Delazio
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: David M. Brienza Ph.D.
Alexandra Marie Delazio
Todd Hargroder
Date Submitted: 2021-12-13